the perspectives of mesenchymal stem cell therapy in the treatment of multiple sclerosis

نویسندگان

nima naderi department of pharmacology and toxicology, school of pharmacy, shahid beheshti university of medical science, tehran, iran

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The Perspectives of Mesenchymal Stem Cell Therapy in the Treatment of Multiple Sclerosis

Currently approved therapies for multiple sclerosis (MS) mostly directed towards palliating inflammation, in particular in those patients with the relapsing–remitting form of MS. However, in a significant number of patients, the disease might be worsen during time. Most importantly, at present there is no therapy available to repair the irreversible neuronal damage, which leads to a progressive...

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mesenchymal stem cell therapy for multiple sclerosis

human mesenchymal stem cell (msc) can be isolated from bone marrow (bm) and differentiated into multiple lineages. these properties make them promising tools in cell and gene therapy. up to now, no definite therapeutic intervention for late stages of multiple sclerosis (ms) has been found. we decided to inject ms patients with autologous expanded msc. five patients participated in this ongoing ...

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Does Mesenchymal Stem Cell Therapy Help Multiple Sclerosis Patients? Report of a Pilot Study

Background: Mesenchymal stem cells (MSCs) with their potential to differentiate into mesodermal and non-mesodermal lineages have several immunomodulatory characteris-tics. These properties make them promising tools in cell and gene therapy. Objective: To evaluate the potential therapeutic applications of autologous MSC in improving clinical manifestations of MS patients. Methods: Ten patients w...

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The Role of Stem Cell Therapy in Multiple Sclerosis: an Overview of the Current Status of the Clinical Studies

The complexity of multiple sclerosis (MS) and the incompetence of a large number of promise treatments in MS urge us to plan new and more effective therapeutic approaches that aim to suppress ongoing autoimmune responses and induction of local endogenous regeneration. Emerging data propose that hematopoietic, mesenchymal and neural stem cells have the potential to restore self-tolerance, to pro...

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عنوان ژورنال:
iranian journal of pharmaceutical research

جلد ۱۴، شماره supplement، صفحات ۱-۲

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